CELL ENGINEERING USING RNAs

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United States of America Patent

SERIAL NO

14400610

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention concerns the field of cell culture technology. It concerns RNA having a specific sequence, expression vectors encoding said RNA, production host cell lines comprising said RNA, and methods of producing recombinant biopharmaceutical products using engineered host cell with altered levels of said RNAs, such as small non-coding RNAs, preferably microRNAs (miRNAs). The invention also relates to engineered host cells with altered levels in one or more of said RNAs. Those cell lines have improved secretion and/or growth characteristics in comparison to control cell lines.

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Patent Owner(s)

Patent OwnerAddress
BOEHRINGER INGELHEIM INTERNATIONAL GMBHGERMANY INGELHEIM AM RHEIN RHINELAND-PALATINATE

International Classification(s)

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  • 2013 Application Filing Year
  • C12P Class
  • 1593 Applications Filed
  • 1388 Patents Issued To-Date
  • 87.14 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Florin, Lore Danbury, US 20 45
Hausser, Angelika Stuttgart, DE 11 18
Kaufman, Hitto Ulm, DE 2 2
Olayioye, Monilola Ulm, DE 13 20
Strotbek, Michaela Asperg, DE 6 3

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  • 1 Citation Count
  • C12P Class
  • 46.51 % this patent is cited more than
  • 10 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges151814501825228186232301 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7081 - 9091 - 100100 +01002003004005006007008009001000110012001300140015001600

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