SPIROSTEROID SYSTEMS ACTING AS NEUROPROTECTIVE AND ANTI-INFLAMMATORY AGENTS
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United States of America Patent
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Issued Date -
May 21, 2015
app pub date -
Dec 27, 2012
filing date -
Dec 27, 2011
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Abandoned
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Abstract
The present invention relates to the fields of chemistry and pharmacy and, in particular, to the production of novel molecular entities: esterane derivatives fused with spirostanes rings, acting upon the Central Nervous Systems (CNS). From diosgenin, a naturally occurring sapogenin, with some subsequent transformations thereof, spirosteroid derivatives of the I-IV general formula can be obtained, with a cyclopentaneperhydrophenantrene nucleus fused to a 25R-spirostanes nucleus. Such molecular entities have an anti-inflammatory and anti-glutamatergic actions that can be used to treat inflammatory, cerebrovascular, neurodegenerative, neuropsychiatric, and neurologic diseases.
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