exchanger NHE3 and their methods of use in gastrointestinal disease

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United States of America Patent

PATENT NO 9850292
SERIAL NO

14400904

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Abstract

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A synthetic peptide modeled on the IRCX binding area of NHE3, is a competitive inhibitor of the IRCX and both stimulates basal NHE3 activity and prevents elevated Ca2+ and cAMP inhibition of NHE3. Methods of its preparation and use in the prevention and/or treatment of gastrointestinal disease, such as diarrhea are provided.

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Patent Owner(s)

Patent OwnerAddress
THE PENNSYLVANIA STATE UNIVERSITY201 OLD MAIN UNIVERSITY PARK PA 16802

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Donowitz, Mark Baltimore, US 5 35
Patterson, Randen University Park, US 2 0
Van, Rossum Damian Brett State College, US 1 0
Zachos, Nicholas Constantine Columbia, US 1 0

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