Compositions and Methods for Reactivating Latent Immunodeficiency Virus
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United States of America Patent
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Issued Date -
May 14, 2015
app pub date -
Mar 13, 2013
filing date -
Mar 28, 2012
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Abandoned
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Abstract
The present disclosure provides compositions and methods for reactivating latent immunodeficiency vims. The methods generally involve contacting an HIV-infected cell in which HIV is latent with an agent that binds a bromodomain (BRD) in the cell. Latently infected cells contain replication-competent integrated HIV-1 genomes that are blocked at the transcriptional level, resulting in the absence of viral protein expression. The present disclosure provides methods for reducing the reservoir of latent immunodeficiency virus in an individual.
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