Stable Solid Formulation of a GC-C Receptor Agonist Polypeptide Suitable for Oral Administration
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United States of America Patent
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Issued Date -
May 14, 2015
app pub date -
Jan 15, 2015
filing date -
Aug 15, 2008
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Abandoned
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Abstract
Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
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