Combination Therapy for Treatment of Cancer
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United States of America Patent
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May 14, 2015
app pub date -
Dec 7, 2012
filing date -
Dec 9, 2011
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Abstract
The present invention provides methods comprising combination therapy for treating cancer. In particular, the present invention provides Wnt pathway inhibitors in combination with MAPK pathway inhibitors for the treatment of cancer and other diseases. In some embodiments, the MAPK pathway signaling activation is due to a mutation in a MAPK pathway component. In some embodiments, the MAPK pathway signaling component is Ras, Raf, MEK, or ERK.
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