MicroRNAs and Uses Thereof
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United States of America Patent
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Issued Date -
May 7, 2015
app pub date -
Mar 8, 2013
filing date -
Mar 8, 2012
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Abandoned
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Abstract
Provided herein are methods for inhibiting expression of DOHH in a cell, and for inhibiting hypusination of eIF5A in a cell, the methods comprising contacting a cell with a miRNA or a nucleic acid molecule encoding the miRNA, wherein the miRNA binds to the 3′UTR of the DOHH mRNA and wherein binding results in a reduction in DOHH expression. Also provided are methods for reducing cellular proliferation and for treating diseases associated with abnormal cellular proliferation.
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