DEVELOPMENT, CHARACTERIZATION, AND USE OF AN ANTI-HYPUSINATED eIF5A ANTIBODY TO DIAGNOSE DIABETES
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United States of America Patent
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Apr 30, 2015
app pub date -
Aug 20, 2014
filing date -
Aug 20, 2013
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Provided herein is a comprehensive characterization of a novel polyclonal antibody (IU-88) that specifically recognizes the hypusinated eIF5A. The antibody IU-88 is useful for the investigation of eIF5A biology, for the development of assays recognizing hypusinated eIF5A, and for methods of treating conditions and diseases that involve the activity of hypusinated eIF5A. The antibody was used to determine that the levels of hypusinated eIF5A were elevated in the pancreatic tissues of patients diagnosed with Type 1 or Type 2 Diabetes.
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