METHOD OF THERAPY AND DIAGNOSIS OF ENDOTHELIAL DYSFUNCTION
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United States of America Patent
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Issued Date -
Apr 30, 2015
app pub date -
Jan 7, 2014
filing date -
Oct 28, 2013
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Abstract
The invention discloses a method of therapy of endothelial dysfunction, by administering microRNA let-7g to a subject in need, wherein the microRNA let-7g inhibits SMAD2 transcription factor from activation and translocation into nucleus, thereby decreasing monocyte cell adhesion, inflammation and thrombosis and increasing angiogenesis.
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