Methods and Compositions for Manipulating the Immune System
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
N/A
Issued Date -
Apr 30, 2015
app pub date -
Mar 15, 2013
filing date -
Apr 20, 2012
priority date (Note) -
Published
status (Latency Note)
Importance
Abstract
Methods and compositions, e.g., therapeutic agents, are provided for modulating gene and/or protein expression of Forkhead Box protein 1 (Foxp1), particularly Foxp1A and Foxp1D, in CD4+ T cells. Such modulation permits manipulation of the B cell response and antibody production and activity, without depleting the number, production or activity of the T cells. In one aspect, methods and compositions for increasing or up regulating the nucleic acid and/or protein expression of Foxp1A, Foxp1D or a combination thereof in the subject's cells in vivo, inhibits or suppresses B cell response and antibody production or activity thereof in the subject. This aspect is useful for treating diseases characterized by excessive B cell response or antibody production or activity, such as autoimmune disorders
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully