METHOD FOR ASSESSING ENDOMETRIAL CANCER SUSCEPTIBILITY

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United States of America Patent

APP PUB NO 20150111769A1
SERIAL NO

14391858

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Abstract

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The present invention aims to provide an assessment method of corpus uteri cancer susceptibility, in which a human chromosomal region consisting of a nucleotide sequence of approximately 100 bps that exhibits a DNA copy number polymorphism associated with corpus uteri cancer susceptibility is identified and assessment is made based on an increase or decrease in the DNA copy number polymorphism. Corpus uteri cancer susceptibility can be assessed by: first, isolating a chromosomal region exhibiting the DNA copy number polymorphism specific for corpus uteri cancer by screening using a microarray derived from the peripheral blood, and subsequently, identifying DNA in a human chromosomal region consisting of a nucleotide sequence shown in any of SEQ ID NOs: 1 to 7, which is associated with corpus uteri cancer susceptibility, from a vast number of chromosomal regions including not only the chromosomal regions isolated by the above screening, but also regions not covered by the microarray, and then detecting a decrease in DNA copy number in the human chromosomal region consisting of the nucleotide sequence shown in any of SEQ ID NOs: 1 to 7.

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Patent OwnerAddress
YAMAGUCHI UNIVERSITY1677-1 YOSHIDA YAMAGUCHI-SHI YAMAGUCHI 753-8511

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Okada, Takae Yamaguchi, JP 2 1
Sasaki, Kohsuke Yamaguchi, JP 5 28
Suehiro, Yutaka Yamaguchi, JP 5 34

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