RAD51C AS A HUMAN CANCER SUSCEPTIBILITY GENE
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United States of America Patent
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Apr 23, 2015
app pub date -
Apr 11, 2011
filing date -
Apr 9, 2010
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Abstract
The invention discloses in vitro methods and a system for determining a predisposition of a subject for developing a cancer on the basis of analyzing a sample of the subject for an alteration of at least one allele of the RAD51C gene. Further disclosed are in vitro methods for assessing clinical features or a pathological progression of a cancer and for assessing at least one RAD51 C gene alteration in a cell. In addition a kit for determining a predisposition of a subject for developing a cancer, and certain uses of oligonucleotides for determining the presence of at least one mono-allelic germ-line mutation of the RAD51C gene.
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