Method for the Selection of Serum Biomarkers of Epigenetic Alterations, Particularly of Global Hypomethylation and Their Uses

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United States of America Patent

APP PUB NO 20150105281A1
SERIAL NO

14394799

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Abstract

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The present invention provides a novel method for the selection of serum biomarkers of epigenetic alterations, particularly of global hypomethylation, and the use of said biomarkers in a method for screening, diagnosing and following a pathology associated to epigenetic alterations of cell in an individual, such as placental-related pathology or cancer. The present invention also relates to a method of detecting a predisposition to placental-related pathology or cancer based on the presence or the level of said biomarker in a serum or plasma sample of said patient. The present invention also relates to a method for predicting and following the effect of drugs targeting epigenetic modifications and in particular the effect of demethylating agents. The present invention is directed to a kit comprising such serum biomarkers of epigenetic alterations, particularly of global hypomethylation.

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Patent Owner(s)

Patent OwnerAddress
INSTITUT CURIE26 RUE D'ULM 75005 PARIS 75005
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)3 RUE MICHEL ANGE PARIS 75016
INSTITUT GUSTAVE ROUSSY39 RUE CAMILLE DESMOULINS VILLEJUIF 94800
UNIVERSITE PARIS DESCARTES12 RUE DE L'ECOLE DE MEDECINE PARIS F-75006

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bellet, Dominique Boulogne-Billancourt, FR 12 337
Pecking, Alain Colombes, FR 2 0
Richon, Sophie L'Isle Adam, FR 3 0

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