METHOD OF CONTINUOUS FERMENTATION PROCESS FOR SUCCINIC ACID BY MICROBIAL CELLS OF ACTINOBACILLUS SUCCINOGENES
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United States of America Patent
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Issued Date -
Apr 16, 2015
app pub date -
Jan 15, 2014
filing date -
Oct 15, 2013
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Abandoned
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Abstract
The present invention relates to a continuous fermentation process using Actinobacillus succinogenes. It was confirmed that in a cell recycled process, a production amount of succinic acid was about 60 g/L and productivity was about 3.873 g/L per hour. It was confirmed that a cell recycled fermentation process was increased in amount of microbial cells by about 2 times or more, increased in production amount of succinic acid by about 5 times, and increased in productivity of succinic acid by about 8 times or more as compared with the typical continuous culture. Such a succinic acid production process with high productivity and high yield rate can reduce production cost and can also produce succinic acid on an industrial level even at a pilot-scale culture unit without scaling up a culture unit. Therefore, if the process of the present invention is applied, it is expected to be more advantageous for industrial application.
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