CYTOMEGALOVIRUS DISINTEGRIN-LIKE PEPTIDES
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United States of America Patent
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Issued Date -
Apr 16, 2015
app pub date -
Oct 16, 2013
filing date -
May 12, 2004
priority date (Note) -
Abandoned
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Abstract
The present invention relates to methods and compositions for inhibiting the entry of viruses, such as herpesviruses into a host cell. A conserved viral integrin-binding gB disintegrin-like domain has been identified that engages integrins and facilitates viral internalization into the host cell. Therefore, methods and compositions, such as antiviral agents encompassing the conserved gB disintegrin-like domain and antibodies thereto are described. These active agents interfere with the interaction between virions and cellular integrins, thereby inhibiting viral infection of a host cell.
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