RADIO-PHARMACEUTICAL COMPLEXES
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United States of America Patent
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Issued Date -
Apr 16, 2015
app pub date -
May 13, 2013
filing date -
May 11, 2012
priority date (Note) -
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Abstract
A tissue-targeting complex comprising a tissue targeting moiety, an octadentate hydroxypyridinone-containing ligand comprising four HOPO moieties and the ion of an alpha-emitting thorium radionuclide, where at least one of the four HOPO moieties is substituted at the N-position with a hydroxyalkyl solubilising group and wherein the tissue targeting moiety has binding affinity for the CD22 receptor. Methods of treatment utilising such complexes and methods of formation of such complexes are provided.
First Claim
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