METHODS FOR ACTIVATING RETROVIRUS IN LATENT INFECTED CELLS, AND COMPOUNDS FOR USE THEREIN
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United States of America Patent
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Issued Date -
Apr 9, 2015
app pub date -
Mar 1, 2013
filing date -
Mar 2, 2012
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a method for increasing retrovirus transcription in an infected eukaryotic cell, comprising increasing Wnt pathway signaling in said cell such that transcription of said retrovirus is increased. Also, the present invention relates to a method of treating a subject infected with a retrovirus, said method comprising administering to said subject an activator of the Wnt pathway in an amount that increased Wnt pathway signaling in resting memory CD4+ T cells of said subject such that the retroviral long terminal repeat (LTR) in said cells is activated or de-repressed.
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