METHODS FOR THE SCREENING OF ANTIBACTERIAL SUBSTANCES
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United States of America Patent
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N/A
Issued Date -
N/A
app pub date -
Oct 7, 2014
filing date -
Aug 2, 2005
priority date (Note) -
Abandoned
status (Latency Note)
Importance
Abstract
The present invention concerns a method for the screening of antibacterial substances comprising a step of determining the ability of a candidate substance to inhibit the activity of a purified enzyme selected from the group consisting of: (i) a D-aspartate ligase comprising a polypeptide having an amino acid sequence possessing at least 50% amino acid identity with an amino acid sequence selected from the group consisting of SEQ ID No 1 to SEQ ID No 10, or a biologically active fragment thereof; and (ii) a L,D-transpeptidase comprising a polypeptide having an amino acid sequence possessing at least 50% amino acid identity with the amino acid sequence of SEQ ID No 11, or a biologically active fragment thereof.
First Claim
Other Claims data not available