METHOD TO PREDICT THE SAFETY OF THE TREATMENT WITH A NICOTINIC CHOLINERGIC RECEPTOR AGONIST
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United States of America Patent
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Apr 2, 2015
app pub date -
Apr 19, 2013
filing date -
Apr 20, 2012
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Abstract
The present invention generally relates to methods for predicting the safety of a nicotinic cholinergic receptor agonist drug-based pharmacological treatment, such as one based on varenicline, based on determining at least one allele of one or more of single-nucleotide polymorphisms (SNPs) rs9479757, rs7930792, rs12423809, rs4251417, rs7146, rs477292, rs495491, rs3778151, rs763132, rs4474069 and rs1183035, or of any SNP of the corresponding linkage groups thereof, in a biological sample of a subject.
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