NOVEL BIFUNCTIONAL METNASE/INTNASE INHIBITORS AND RELATED COMPOSITIONS AND METHODS OF TREATMENT OF CANCER

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United States of America Patent

APP PUB NO 20150087886A1
SERIAL NO

14510476

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Abstract

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This invention relates to novel cancer treatment compositions and associated therapeutic methods. More particularly, this invention relates in part to small chemical bifunctional inhibitors of DNA replication and repair proteins Metnase and/or Intnase (also termed Gypsy Integrase, Gypsy Integrease-1, Gypsy Retransposon Integrase 1, or GIN-1) that simultaneously damage DNA, and to a therapeutic method that utilizes the inhibitors to increase the effectiveness of cancer treatment protocols, including radiation therapy.

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Patent Owner(s)

Patent OwnerAddress
STC UNM801 UNIVERSITY BLVD SE SUITE 101 ALBUQUERQUE NM 87106

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hromas, Robert Gainsville, US 6 16
Leitao, Andrei San Carlos, BR 3 1
Oprea, Tudor I Albuquerque, US 10 42
Sklar, Larry A Albuquerque, US 58 580
Wang, Wei Albuquerque, US 2815 17926
Williamson, Elizabeth A Gainsville, US 3 1
Wray, Justin Albuquerque, US 3 1

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