Matrix Metalloproteinase Substrates And Other Cleavable Moieties And Methods Of Use Thereof
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United States of America Patent
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Sep 25, 2014
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Sep 25, 2013
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The invention relates generally to polypeptides that include a cleavable moiety that is a substrate for at least one matrix metalloprotease (MMP), to activatable antibodies and other larger molecules that include the cleavable moiety that is a substrate for at least one MMP protease, and to methods of making and using these polypeptides that include a cleavable moiety that is a substrate for at least one MMP protease in a variety of therapeutic, diagnostic and prophylactic indications.
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