DIFFERENTIATED HUMAN LIVER CELL CULTURES AND THEIR USE IN BIOARTIFICIAL LIVER SYSTEMS

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United States of America Patent

SERIAL NO

14541164

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Abstract

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Human hepatocyte cell cultures and their use in bioreactors and bioartificial liver (BAL) systems are provided. The cells have constitutive liver-specific metabolic activity resembling that of freshly isolated human hepatocytes. The hepatocyte cells and BAL systems can be used to treat patients suffering from acute liver failure, end-stage liver disease, or acute-on-chronic liver disease.

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Patent Owner(s)

Patent OwnerAddress
ACADEMISCH ZIEKENHUIS BIJ DE UNIVERSITEIT VAN AMSTERDAM1105 AZ AMSTERDAM

International Classification(s)

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  • 2014 Application Filing Year
  • C12N Class
  • 5730 Applications Filed
  • 4275 Patents Issued To-Date
  • 74.61 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CHAMULEAU, Robert Antoine Francois Marie BUSSUM, NL 1 0
HOEKSTRA, Ruurdtje WEESP, NL 3 8
NIBOURG, Gerardus Adrianus Antonius AMSTERDAM, NL 2 8

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges24532564290903213641301 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7091 - 100100 +02004006008001000120014001600180020002200240026002800

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