STABLE READY-TO-USE PHARMACEUTICAL COMPOSITION OF PEMETREXED
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United States of America Patent
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Issued Date -
Mar 12, 2015
app pub date -
Mar 25, 2013
filing date -
Mar 27, 2012
priority date (Note) -
Abandoned
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Abstract
A stable ready-to-use pharmaceutical composition comprising pemetrexed or pharmaceutically acceptable salts thereof, wherein the composition is free from antioxidants, amino acids and chelating agents. Also provided is a process for preparing a stable ready-to-use pharmaceutical composition comprising the steps: i) purging inert gas into a parenterally acceptable aqueous solvent until the dissolved oxygen content of the solvent comes to less than 7 mg/L, preferably less than 3 mg/L; ii) adding pemetrexed disodium under stirring; iii) adjusting the pH of the resulting solution to between 4 to 9; iv) optionally adding additional aqueous solvent; wherein the composition is purged with inert gas throughout the entire process.
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