Genetically Modified Organisms for Increased Microbial Production of 3-Hydroxypropionic Acid Involving an Oxaloacetate alpha-decarboxylase
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United States of America Patent
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Issued Date -
Mar 12, 2015
app pub date -
Jul 25, 2014
filing date -
Sep 27, 2009
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Abandoned
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Abstract
Microorganism compositions are described that comprise combinations of genetic modifications that include a genetic modification to increase oxaloacetate alpha-decarboxylase enzymatic activity. By such genetic modification a 3-hydroxypropionic acid (“3-HP”) production pathway is provided or improved. In various embodiments, comprising other genetic modifications, including selected gene disruptions, 3-HP production is greater than in a control microorganism lacking such combinations of genetic modifications
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