LIPOSOMES FOR HEMATOLOGICAL TUMORS
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United States of America Patent
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Issued Date -
Mar 12, 2015
app pub date -
Sep 5, 2014
filing date -
Sep 6, 2013
priority date (Note) -
Abandoned
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Abstract
Targeted liposomes containing chemotherapeutic compounds of Formula (I) are provided for treating hematological cancers. The targeted liposomes can be targeted to cancer cells (e.g., malignant B cells) by attachment to an antibody or antibody fragment of a suitable cell surface antigen, e.g., CD22. The targeted liposomes have higher IC50s for cells not having the cell surface antigen as compared to similar non-targeted liposomes. Also provided are methods of preparing the targeted liposomes.
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