INHIBITING INTERACTION BETWEEN HIF-1ALPHA AND p300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES

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United States of America Patent

SERIAL NO

14476394

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Abstract

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The present invention relates to peptidomimetics that mimic helix αB of the C-terminal transactivation domain of HIF-1α. Methods of using the peptidomimetics to, e.g., inhibit the HIF-1α-p300/CBP interaction, are also disclosed.

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NEW YORK UNIVERSITY70 WASHINGTON SQUARE SOUTH NEW YORK NY 10012

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
ARORA, Paramjit S Cold Spring Harbor, US 28 143
HENCHEY, Laura K New York, US 1 2
KUSHAL, Swati Los Angeles, US 1 2
LAO, Brooke Bullock Leesville, US 8 31
OLENYUK, Bogdan Z Sierra Madre, US 7 18
THOMSON, Paul New York, US 37 133
TRAASETH, Nathaniel J New York, US 1 2

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