METHODS FOR TREATMENT OF CERVICAL INSUFFICIENCY
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United States of America Patent
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Issued Date -
Mar 5, 2015
app pub date -
Sep 21, 2012
filing date -
Sep 23, 2011
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Abstract
Methods, compositions, devices and kits for increasing mechanical stiffness of an incompetent or a dilated biological tissue in a subject are provided herein. The methods described herein involve placing (e.g., injecting) a silk fibroin-based composition into at least a portion of an incompetent or dilated tissue of a subject. In some embodiments, the silk fibroin-based composition can further comprise at least two PEG components that will crosslink together upon placement (e.g., injection) into a subject in need thereof. In specific embodiments, the methods, compositions, devices and kits can be used to increase mechanical stiffness of a cervical tissue in a subject, for example, for treatment of cervical insufficiency.
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