EXPRESSION CONSTRUCTS AND METHODS FOR EXPRESSING POLYPEPTIDES IN EUKARYOTIC CELLS
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United States of America Patent
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Issued Date -
Feb 26, 2015
app pub date -
Aug 6, 2014
filing date -
Aug 6, 2013
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Abandoned
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Abstract
The invention relates to an expression construct for the expression of polypeptides in host cells using alternative splicing. The expression construct can be used for the expression of polypeptides such as antibodies, antibody fragments and bispecific antibodies by expressing the gene products required for protein expression at the ratio leading to the highest titres or the best product quality profile.
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