METHOD FOR IDENTIFICATION OF THE SEQUENCE OF POLY(A)+RNA THAT PHYSICALLY INTERACTS WITH PROTEIN
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United States of America Patent
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Feb 12, 2015
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Mar 18, 2013
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Mar 16, 2012
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Abstract
The invention relates to an in vitro method for identifying the sequence of one or more poly(A)+RNA molecules that physically interacts with protein. The present invention provides a method to define the protein-bound transcriptome under any given cellular condition, such as a disease condition or after treatment with any given substance, drug, or other cellular perturbation. The invention also relates to a method for identification of a drug target and a method for the identification of one or more biomarkers, preferably for identification of a panel of biomarkers, for any given medical condition, comprising the method of the invention.
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