SPHINGOLIPID METABOLITE MIMETICS

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United States of America Patent

SERIAL NO

14511296

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Abstract

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Sphingolipid metabolite mimetics and methods of synthesizing them are provided. The sphingolipid metabolite mimetics are shown to be effective at inducing apoptosis in various types of tumor cells. Further, the sphingolipid metabolite mimetics are shown to be effective at sensitizing multiple types of tumor cells to TRAIL-induced apoptosis. Formulations containing one or more sphingolipid metabolite mimetics and, optionally, one or more cell death receptor agonists are provided. Methods of treating cancer in a subject in need thereof are provided using one or more sphingolipid metabolite mimetics.

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Patent Owner(s)

Patent OwnerAddress
ZHEJIANG UNIVERSITY866 YUHANGTANG ROAD XIHU DISTRICT HANGZHOU CITY ZHEJIANG PROVINCE 310058

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huang, Zhizhen Hangzhou, CN 6 0
Liu, Feiyan Hangzhou, CN 3 27
Liu, Kebin Augusta, US 8 81
Wu, Ping Hangzhou, CN 213 1832

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