Chemical Modification of Antibodies
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United States of America Patent
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Jan 29, 2015
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Mar 8, 2013
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Mar 9, 2012
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Abstract
The present invention relates to antibodies and antibody fragments, one or more of whose native inter-chain disulfide bridges have been replaced with a specific bridging moiety. The bridging moiety can be selectively targeted to inter-chain disulfide bonds within the antibody or antibody fragment, enabling the construction of more homogenously modified products such as antibody-drug conjugates.
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