METHOD OF MEASURING IMMUNE ACTIVATION
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United States of America Patent
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Issued Date -
Jan 29, 2015
app pub date -
Dec 12, 2012
filing date -
Dec 13, 2011
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Abandoned
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Abstract
The invention is directed to a method of detecting immune activation in an individual by measuring frequencies and sizes of certain groups of related clonotypes, referred to herein as “clans,” in a clonotype profile of the individual. A clan may arise from a single lymphocyte progenitor that gives rise to many related lymphocyte progeny, each possessing and/or expressing a slightly different immunoglobulin receptor due to somatic mutation(s), such as base substitutions, inversions, related rearrangements resulting in common V(D)J gene segment usage, or the like. Immune activation is correlated to frequencies and sizes of clans in a clonotype profile exceeding reference values for those features.
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