COMPOSITIONS AND METHODS FOR INDUCING APOPTOSIS

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United States of America Patent

APP PUB NO 20150025127A1
SERIAL NO

14238304

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Methods and compositions are provided for generating novel nucleic acid molecules through targeted spliceosome mediated RNA trans-splicing (SMaRT™) that result in expression of a splicing isoform or variant thereof. The methods and compositions are based upon pre-trans-splicing molecules (PTMs) designed to interact with a target pre-mRNA molecule and mediate a trans-splicing reaction generating a novel chimeric RNA molecule encoding a splicing isoform for the treatment of a variety of gene isoform induced diseases such as cancer.

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Patent Owner(s)

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VIRXSYS CORPORATION200 PERRY PARKWAY SUITE 1A GAITHERSBURG MD 20877

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Inventor Name Address # of filed Patents Total Citations
McGarrity, Gerard John Gaithersburg, US 1 0

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