PRODRUGS OF D-GAMMA-GLUTAMYL-D-TRYPTOPHAN AND D-GAMMA-GLUTAMYL-L-TRYPTOPHAN

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United States of America Patent

APP PUB NO 20150011484A1
SERIAL NO

14008951

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Abstract

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The present invention provides pro-drugs of D-gamma-glutamyl-[D/L]-tryptophan, said pro-drugs are compounds of Formula I or pharmaceutically acceptable salts thereof, wherein G is C1-C8 alkyl or benzyl, T is C1-C8 alkyl or benzyl, and * is a chiral carbon in a (R) or (S) configuration, provided that when * is in the (R) configuration, at least one of G and T is C5-C8 alkyl; and use of compounds of Formula I in a pharmaceutical composition.

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APOTEX TECHNOLOGIES INCTORONTO ON M9L 1T9

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Feeney, Christopher John Toronto, CA 11 54
Leung-Toung, Regis Mississauga, CA 21 49
Li, Wanren Toronto, CA 16 122
Rabadia, Vrajlal S Mississauga, CA 3 8
Shah, Birenkumar Brampton, CA 8 8
Tam, Tim Fat Vaughan, CA 46 240
Wang, Yinsheng Toronto, CA 4 2
Wodzinska, Jolanta Maria Mississauga, CA 11 22
Xin, Tao Vaughan, CA 83 443
Zhao, Yanqing Richmond Hill, CA 28 69

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