BI-FUNCTIONAL COMPOSITIONS FOR TARGETING CELLS TO DISEASED TISSUES AND METHODS OF USING SAME
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United States of America Patent
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app pub date -
Jul 16, 2014
filing date -
Oct 27, 2009
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Abstract
Disclosed herein are compositions and methods for the targeted delivery of therapeutic cells to a target tissue. In several embodiments, the therapeutic cells are captured by an antibody that is coupled to a magnetic particle, which is in turn coupled to an antibody directed against a specific marker expressed by a target tissue. In some embodiments, the therapeutic cells comprise the target tissue is damaged or diseased cardiac tissue. In several embodiments, in conjunction with an applied magnetic field, the methods, in combination with the compositions, yield enhanced delivery, of the therapeutic cells to the target tissue, thereby resulting in repair and/or regeneration of the target tissue. Also disclosed are methods for the non-invasive detection of immune responses to transplanted cells or organs.
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