Treatment of Heart Failure and Sudden Cardiac Death
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United States of America Patent
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Issued Date -
Jan 1, 2015
app pub date -
Jan 3, 2013
filing date -
Jan 3, 2012
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Abstract
A method of reducing heart failure or preventing sudden cardiac death in a subject in need thereof is carried out by administering a composition comprising a compound that increases cellular level of Sarco/endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a). The invention represents a significant breakthrough in the treatment or prevention of chronic heart failure. The invention is based upon the discovery that a Mifepristone molecule increases the cellular level of SERCA2a protein.
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