METHODS FOR CONJUGATION OF OLIGOSACCHARIDES OR POLYSACCHARIDES TO PROTEIN CARRIERS THROUGH OXIME LINKAGES VIA 3-DEOXY-D-MANNO-OCTULSONIC ACID

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United States of America Patent

APP PUB NO 20140378669A1
SERIAL NO

14316662

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Abstract

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Methods for preparing an oligosaccharide—protein carrier immunogenic conjugate or a polysaccharide—protein carrier immunogenic conjugate. The methods include obtaining an oligosaccharide or polysaccharide having a KDO moiety located at the terminal reducing end of the oligosaccharide or polysaccharide that includes a carbonyl functional group; and reacting the carbonyl functional group of the KDO moiety with an aminooxylated protein carrier molecule resulting in a conjugate that includes a covalent oxime bond between the oligosaccharide and the protein carrier or the polysaccharide and the protein carrier.

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NATIONAL RESEARCH COUNCIL OF CANADA1200 MONTREAL ROAD OTTAWA K1A 0R6

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ben-Menachem, Gil Rockville, US 4 2
Ginzberg, Ariel Jerusalem, IL 2 1
Kubler-Kielb, Joanna Bethesda, US 23 43
Langergard, Teresa Kullavik, SE 1 0
Pozsgay, Vince Washington, US 10 47
Schneerson, Rachel Bethesda, US 36 170
Vinogradov, Evguenii Ottawa, CA 10 27

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