HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING
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United States of America Patent
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Issued Date -
Dec 18, 2014
app pub date -
Feb 12, 2014
filing date -
Feb 12, 2013
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Abstract
In certain embodiments hydantoin compounds are provided herein that are effective to inhibit BACE activity against APP. Without being bound to a particular theory, it is believed the activity of the hydantoins identified herein appears to be associated with binding to BACE and/or to APP particularly when these moieties form a BACE/APP complex. Accordingly, it is believed the compounds described herein represent a new class of compounds designated herein as APP-Binding-BACE Inhibitors (ABBIs) and provide a new mechanism to modulate APP processing. The hydantoins described herein appear to show improved brain permeability and functional BACE inhibition.
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