Reengineering mRNA Primary Structure for Enhanced Protein Production
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United States of America Patent
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Issued Date -
Dec 18, 2014
app pub date -
Sep 4, 2014
filing date -
Feb 24, 2009
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Abstract
Described herein are rules to modify natural mRNAs or to engineer synthetic mRNAs to increase their translation efficiencies. These rules describe modifications to mRNA coding and 3′ UTR sequences intended to enhance protein synthesis by: 1) decreasing ribosomal diversion via AUG or non-canonical initiation codons in coding sequences, and/or 2) by evading miRNA-mediated down-regulation by eliminating one or more miRNA binding sites in coding sequences.
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