MODULATION OF PEPTIDOME USING HISTONE DEACETYLASE INHIBITOR
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United States of America Patent
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Issued Date -
Dec 18, 2014
app pub date -
Feb 20, 2013
filing date -
Feb 22, 2012
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Abandoned
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Abstract
Provided herein is a method of modulating an APC peptidome comprising identifying an APC or an APC cell population that expresses an HDACi-associated polypeptide and administering an HDACi to the APC. Also provided herein is a method of identifying an HDACi-associated peptide comprising administering an HDACi to an APC, isolating the polypeptide from an APC MHC molecule binding cleft, and identifying the polypeptide.
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