MULTI-SPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF

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United States of America Patent

SERIAL NO

14019117

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Abstract

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Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.

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Patent Owner(s)

Patent OwnerAddress
CHUGAI SEIYAKU KABUSHIKI KAISHA5-1 UKIMA 5-CHOME KITA-KU TOKYO 1158543 ?1158543

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Igawa, Tomoyuki Shizuoka, JP 244 5997
Imai, Chifumi Shizuoka, JP 12 235
Kitazawa, Takehisa Shizuoka, JP 24 363
Kojima, Tetsuo Shizuoka, JP 92 1686
Muto, Atsushi Shizuoka, JP 44 340
Nishida, Yukiko Shizuoka, JP 13 239
Sampei, Zenjiro Shizuoka, JP 39 534
Soeda, Tetsuhiro Shizuoka, JP 34 649
Suzuki, Tsukasa Shizuoka, JP 23 382
Yoshihashi, Kazutaka Shizuoka, JP 14 230

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