SINGLE SHOT HIGH RESOLUTION CONJUNCTIVAL SMALL VESSEL PERFUSION METHOD FOR EVALUATING MICROVASCULATURE IN SYSTEMIC AND OCULAR VASCULAR DISEASES
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United States of America Patent
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Issued Date -
Dec 4, 2014
app pub date -
May 28, 2014
filing date -
May 29, 2013
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Abstract
A system and method for generating high-resolution, small vessel perfusion maps (nCPMs) of the ocular conjunctival microvasculature. Unlike current systems and methods, the present invention allows for the generation of nCPMs using only a single raw image obtained in a single image acquisition step. The method includes obtaining a single raw image of at least a portion of the microvasculature of the ocular conjunctiva. The raw image may be obtained using a digital camera and slit lamp. The red and blue color channels are removed from the raw image to create a color-adjusted image in which contrast between the microvasculature and the sclera is enhanced. The color-adjusted image is then inverted and saved as a grayscale inverted image. The grayscale inverted image may be skeletonized. The grayscale image and/or the skeletonized image may be quantitatively analyzed.
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