METHOD FOR INHIBITING EZH2 EXPRESSION IN BREAST CANCER CELLS
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United States of America Patent
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Issued Date -
Dec 4, 2014
app pub date -
May 28, 2014
filing date -
May 30, 2013
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Abandoned
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Abstract
The present invention is directed to a method for inhibiting the overexpression of EZH2 in breast cancer cells. The method comprises administering to breast cancer cells an effective amount of YC-1 (3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole), YC-1-succinate (succinic acid mono-[5-(1-benzyl-1H-indazol-3-yl)-furan-2-ylmethyl]ester), or a pharmaceutically acceptable salt thereof. The present invention is also directed to treating breast cancer comprising administering to a subject an effective amount of YC-1-succinate.
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