USE OF N-HYDROXYSUCCINIMIDE TO IMPROVE CONJUGATE STABILITY
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United States of America Patent
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Issued Date -
Nov 27, 2014
app pub date -
Dec 13, 2012
filing date -
Dec 13, 2011
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Abandoned
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Abstract
The invention provides processes for manufacturing cell-binding agent-cytotoxic agent conjugates of improved stability in the presence of exogenous NHS. In some embodiments, the inventive process comprises the addition of a molar ratio of exogenous NHS with respect to the amount of NHS generated during the modification reaction as a result of hydrolysis/aminolysis of the bifunctional linker.
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