Hydrolytically Degradable Micellar Hydrogels
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United States of America Patent
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Issued Date -
Nov 27, 2014
app pub date -
Apr 24, 2014
filing date -
Apr 24, 2013
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Abstract
Degradable and biologically inert hydrogel networks are described. The hydrogel networks are crosslinked and based on a biocompatible polymer that is chain extended with hydrophobic segments that include no more than 5 hydrophobic monomers to form a macromonomer that is then crosslinked to form a network that includes individual micelles throughout the crosslinked network. The hydrophobic segments of the macromonomer as well as other potentially toxic materials such as crosslink initiators can be sequestered in the micelles to better control degradation characteristics of the network as well as prevent toxicity to developing cellular structures of the network.
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