MBTH-LIKE PROTEINS IN THE PRODUCTION OF SEMI SYNTHETIC ANTIBIOTICS

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United States of America Patent

APP PUB NO 20140349340A1
SERIAL NO

14374137

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to the preparation of β-lactam antibiotics comprising contacting 4-hydroxyphenylglycine or phenylglycine, cysteine and valine with a non-ribosomal peptide synthetase and subsequent cyclization using an isopenicillin N synthase in the presence of an MbtH-like protein and to a host cell equipped to perform such preparation.

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Patent Owner(s)

Patent OwnerAddress
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B V2613 AX DELFT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boer, Rémon Echt, NL 3 1
Bovenberg, Roelof Ary Lans Echt, NL 26 87
Mueller, Ulrike Maria Echt, NL 5 9

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