MODIFIED ADENOVIRAL VECTORS AND METHODS OF TREATMENT USING SAME
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United States of America Patent
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Issued Date -
Nov 27, 2014
app pub date -
Sep 7, 2012
filing date -
Sep 9, 2011
priority date (Note) -
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status (Latency Note)
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Abstract
The present invention relates to recombinant adenovirus serotype 5 (Ad5) vectors which harbor chimeric capsid proteins including substitutions of the corresponding regions from adenovirus serotypes having a lower seroprevalence relative to Ad5. In particular, the chimeric capsid includes modifications of both the adenoviral hexon and fiber proteins. The invention also provides methods for the treatment of diseases or disorders caused by infective agent(s) by administering the adenoviral vector(s) to a subject (e.g., a mammal, such as a human).
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| Country | kind | publication No. | Filing Date |
|---|---|---|---|
| WO | A2 | WO2013036791 | Sep 07, 2012 |
International Classification(s)
- 2012 Application Filing Year
- C12N Class
- 5020 Applications Filed
- 3417 Patents Issued To-Date
- 68.07 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 42 Citation Count
- C12N Class
- 98.60 % this patent is cited more than
- 11 Age