Stabilizing RNA by Incorporating Chain-Terminating Nucleosides at the 3'-Terminus
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United States of America Patent
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Nov 20, 2014
app pub date -
Jan 3, 2013
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Jan 4, 2012
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Abstract
A method is disclosed for stabilizing histone stem-loop-containing mRNA by the addition of a chain-terminating nucleoside. The novel, synthetic mRNA contains a 3′ histone stem-loop sequence. At the 3′ end of the mRNA a chain-terminating nucleoside is incorporated, for example 3′-deoxyadenosine (cordycepin). The chain-terminating nucleoside blocks the addition of a 3′-terminal oligo(U) sequence to the mRNA containing the histone stem-loop. When the 3′-terminal oligo(U) sequence cannot be added, degradation of the mRNA is retarded. The mRNA then remains available to the translational machinery for a longer time, resulting in higher levels of protein synthesis.
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