ANTI-ALPHA2 INTEGRIN ANTIBODIES AND THEIR USES
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United States of America Patent
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Issued Date -
Nov 20, 2014
app pub date -
May 19, 2014
filing date -
Nov 18, 2005
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Abstract
The invention relates to anti-α2 integrin antibodies and their uses. Humanized antibodies are disclosed that bind to the I domain of α2 integrin and inhibit the interaction of α2β1 integrin with collagen. Also disclosed are therapeutic uses of anti-α2 integrin antibodies in treating α2β1-mediated disorders, including anti-α2 integrin antibodies that bind to α2 integrin without activating platelets.
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