ANTIBODIES TO 25-HYDROXYVITAMIN D2 AND D3 AND USES THEREOF

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United States of America Patent

APP PUB NO 20140336156A1
SERIAL NO

14335686

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Abstract

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Provided herein are antigenic molecules that can be used to generate antibodies capable of binding to a vitamin D derivative, such as 25-hydroxyvitamin D2 and/or 25-hydroxyvitamin D3, or a 25-hydroxyvitamin D analog, such as a vitamin D-C22 immunogenic molecule or compound. Antibodies produced using these antigenic molecules, and related antigenic compounds, are also described. In addition, disclosed herein are methods for detecting vitamin D deficiency in a subject, methods for treating a subject suspected of having a vitamin D deficiency, methods for monitoring progression of vitamin D deficiency in a subject, and methods for monitoring treatment of vitamin D deficiency in a subject in need thereof. The methods involve the detection or quantification of 25-hydroxyvitamin D2 and D3. Also provided are methods and reagents for the detection or quantification of 25-hydroxyvitamin D2 and D3, methods for stabilizing vitamin D analogs, and methods for separating 25-hydroxyvitamin D2 and D3 from vitamin D binding protein in a biological sample.

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Patent Owner(s)

Patent OwnerAddress
SIEMENS HEALTHCARE DIAGNOSTICS INC511 BENEDICT AVENUE TARRYTOWN NY 10591

International Classification(s)

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  • 2014 Application Filing Year
  • G01N Class
  • 10055 Applications Filed
  • 7887 Patents Issued To-Date
  • 78.44 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2014201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Campbell, Bruce A Calabasas, US 7 36
EVANGELISTA, RAMON A LAGUNA HILLS, US 10 159
FREEMAN, JAMES Vincent SANDY HOOK, US 6 24
Liao, Qimu Alhambra, US 8 25
Lin, Spencer Hsiang-Hsi Yorktown Heights, US 6 24
SAHAKIAN, NIVER PANOSIAN ENCINO, US 6 24

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